Endocrine Abstracts

Maternal nutrient restriction (NR) during late-gestation can influence liver growth by altering maturation of the hypothalamus. Maternal NR during late-gestation increases fetal plasma GH levels whilst circulating IGF-I and IGF-II levels decrease. This study aimed to determine whether maternal NR during late-gestation altered the hepatic IGF system in resultant offspring.Fourteen primiparous twin pregnant Border Leicester cross Swaledale ewes were fed <i...

The abundance of class 1 cytokine receptors for hepatic growth hormone (GH) and long form of prolactin (PRL) receptor peak near to term coincident with the rise in fetal plasma PRL. The extent to which maintenance of high plasma PRL may alter mRNA abundance for the GH or PRL receptors is not known. The present study aimed to determine whether chronic administration of PRL alters the hepatic GH and/or prolactin (PRL) receptor mRNA abundance in livers of 1-week-old lambs.<p ...